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Sevoflurane inhibits JUN. 4 / 4
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"Sevoflurane inhibited activation of the transcription factor AP-1."
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"144 In isolated T cells, sevoflurane inhibited activation of the transcription factor Activator Protein-1 (AP-1), which was associated with the inhibition of p38 activity and resulted in a decreased IL-3 expression."
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"However, in vitro studies using human CD3 T cells showed that sevoflurane suppressed activation of transcription factor AP-1, which plays a role in T cell inflammatory activation [XREF_BIBR] as well as inducing apoptosis [XREF_BIBR]."
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"Sevoflurane inhibits phorbol-myristate-acetate-induced activator protein-1 activation in human T lymphocytes in vitro : potential role of the p38-stress kinase pathway."
15329596