IndraLab

Statements

COPS6 inhibits SPOP. 4 / 4
| 4
reach
"Mechanistically, CSN6 antagonizes speckle-type POZ protein (SPOP) ubiquitin ligase to stabilize HMGCS1, which in turn activates YAP1 to promote tumor growth."
38308184
reach
"In the diethylnitrosamine plus CCl mouse model, CSN6 antagonizes speckle-type POZ protein (SPOP) and stabilizes hydroxymethylglutaryl-CoA synthase 1 (HMGCS1), resulting in YAP activation through the mevalonate pathway."
38874747
reach
"CSN6 negatively regulates SPOP to stabilize HMGCS1, which activates YAP via mevalonate metabolism."
38308184
reach
"All these data suggested that CSN6 promotes SPOP degradation via E3 ligase MDM2."
38308184