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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CALR binds ABCA1 and LXRα. 1 / 1

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"The promising anti-inflammatory effect of SSa on LPS-stimulated primary mouse macrophages is associated with up-regulation of the LXRα-ABCA1 pathway which result in disrupting lipid rafts and reducing translocation of TLR4 to lipid rafts, thereby suppressing TLR4 mediated NF-κB and IRF3 signaling pathways induced by LPS."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...