IndraLab

Statements

KCNH2 inhibits Ala-Pro. 10 / 10
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"The ' selective inhibition ' of the hERG channels by Dofe45 would induce a substantial prolongation of the AP."
28681507
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"Hence, as illustrated in Figure XREF_FIG D, selective hERG inhibition by 300nM Dofe45 would induce a more pronounced AP prolongation."
28681507
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"At 1muM ibogaine, the simulations revealed that hERG current inhibition slightly prolongs the duration of the AP, when compared to the drug-free control condition (XREF_FIG a)."
23707769
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"Blockade of the hERG potassium channel prolongs the ventricular action potential (AP) and QT interval, and triggers early after depolarizations (EADs) and torsade de pointes (TdP) arrhythmia."
26975508
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"Compared with the AP prolongation produced by HERG block in the control myocyte (23.7 ms), Trial # 97 showed a smaller response (DeltaAPD = 15.9 ms) whereas Trial # 270 exhibited a more dramatic response (DeltaAPD = 45.3 ms)."
21699863
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"HERG channel inhibition and concomitant retardation of AP repolarization caused by therapeutic plasma concentrations of any drug are well-known predictors of an increased risk for TdP arrhythmias and sudden cardiac death [XREF_BIBR]."
27020671
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"First hERG blockade prolonged the AP."
23707769
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"Dofetilide (XREF_FIG) is a well-known hERG blocker that triggers AP prolongation and repolarization abnormalities, such as EAD and RF."
33841140
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"Applying multivariable regression to this pseudo-dataset quantified the contribution of each channel property to the AP prolongation produced by HERG block."
21699863
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"Computational modeling supported the concept that this bupivacaine induced AP instability and the AP prolongations in the control and LQT1 like myocytes were caused by inhibition of hERG channels."
22003215