IndraLab

Statements

RL3 activates KCNQ1. 2 / 2
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reach
"R-L3 potentiates the homomeric KCNQ1 channel at very low concentration, but does not affect the KCNQ1 and KCNE1 complex."
23251633
reach
"Using a pharmacological tool compound R-L3 (L-364,373 [(3-R) -1,3-dihydro-5-(2-fluorophenyl)-3-(1H-indol- 3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one]), which activates KCNQ1 and mink channels, we then developed and validated a non radioactive rubidium (Rb+) efflux assay that directly measures the functional activity of KCNQ1 and KCNE1 channels by atomic absorption spectroscopy."
16945016