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APC-CDH1 complex inhibits USP37. 1 / 1

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eidos

"B In the late G2 / M phase , USP37 acts as a substrate of the APC / C complex via phosphorylation by PLK1 and is further ubiquitinated by betaTrCP for the biphasic degradation , resulting in the downregulation of USP37 , necessary for the G2 / M phase transition Interestingly , the APC-CDH1 complex degrades USP37 in late mitosis by targeting its KEN box degron ."

| PMC

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IndraLab

Statements

APC-CDH1 complex inhibits USP37. 1 / 1

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