IndraLab

Statements

MGMT binds USP19. 12 / 12
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"Furthermore, our results show that USP19‐MGMT axis related to the MGMT‐positive GBM cell response to TMZ treatment."
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"To gain more proof to certify the biological function of USP19‐MGMT axis in GBM cells chemo‐resistance in vivo, we employed shRNA to specifically knockdown USP19 in T98G cells, and nude mice were subcutaneously implanted with T98G USP19 depletion cells and control (Ctrl) cells."
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"Mechanistically, USP19 binds to MGMT and then deubiquitinates MGMT, causing the removal of ubiquitin chains, which stabilize MGMT."
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"Additionally, endogenous immunoprecipitation further confirmed that MGMT binds to USP19 (Figure 2B)."
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"To further investigate the mechanism of binding between USP19 and MGMT, we found that the N terminal (1‐596aa) and UI domain of USP19 were responsible for binding with MGMT (Figure 2C).2.3 USP19 deubiquitinates MGMT in vivo and in vitro."
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"Since USP19‐MGMT axis regulates the sensitivity of GBM to TMZ, we analyzed the overall survival of GBM patients in different USP19 expression backgrounds."
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"Mechanistically, USP19 binds to MGMT and then deubiquitinates MGMT, causing the removal of ubiquitin chains, which stabilize MGMT."
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"In this study, we found that the DNA O6‐methylation lesions repair is dependent on the USP19‐MGMT axis, which is a new perspective to intervene in the mechanism of alkylation lesions repair, especially the TMZ treatment for GBM patients."
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"Our study reports the potential of USP19‐MGMT axis as a new chemotherapy target and biomarker in GBM patients."
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No evidence text available
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"To further investigate the mechanism by which USP19 regulates MGMT protein level, we tested whether the USP19 interacts with MGMT."
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"Additionally, endogenous immunoprecipitation further confirmed that MGMT binds to USP19 (Figure  xref )."
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