IndraLab

Statements

Ramipril inhibits ACE2. 7 / 7
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"The ACE inhibitor ramipril did not reduce ACE2 enzymatic activity."
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"found that the ACEI ramipril reduced cardiac ACE2 activity to the level of the control group in a rat model of acute kidney injury (AKI)."
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"In STNx rats, ramipril reduced blood pressure (P < 0.01), polyuria (P < 0.05) and plasma ACE2 (P < 0.01), increased plasma Ang-(1-7) (P < 0.001), and inhibited renal ACE (P < 0.001)."
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"In a CRF model of SD rats, ACE2 mRNA was repressed in the cortex and medulla, with reversal to the no/marginal change level by ramipril [XREF_BIBR]."
33750913
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"5 However , conflicting evidence can also be found , with ramipril failing to increase ACE2 despite a similar duration of ACE inhibition ."
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"In our study using the db/db mice model, we did not find that ramipril reduced ACE2 activity in the kidney (XREF_FIG D and XREF_FIG A) and we neither observed protein internalization (XREF_FIG)."
33811970
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"Our data provide experimental in vivo evidence that the ACE inhibitor Ramipril selectively increases pulmonary ACE2 receptor mRNA and protein levels and reduces acylcarnitines."
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