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"The interaction between AKAP150 and long QT syndrome 8 (LQT8) is also known as Timothy syndrome and is characterized by a single amino acid substitution (G406R) in the L‐type Ca (Ca 1.2) channel.87 Disruption of AKAP150 improves pathological Ca 1.2‐LQT8 channel gating and arrhythmias and prevents hypertrophy of LQT8 hearts by decreasing Ca influx via Ca 1.2‐LQT8 channels.88
AKAP150 is essential for sympathetic stimulation of the Ca transient."