IndraLab

Statements

Dihydroartemisinin inhibits NFKB1. 7 / 7
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"DHA-decreased Wnt5a expression is concurrent with a drop in NFkB-driven inflammatory cytokine expression, revealing mechanisms after stroke, as in RPE cells exposed to UOS."
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"DHA also increases lipoxins, inhibits NFkb, and produces neuroprotectin-D and resolvins, which are important for complete resolution of the inflammatory process [31]; it is important to underline that the incomplete resolution of an inflammatory response can be a significant contributor to chronic and exacerbating disease and pain development.Our in vitro acute toxicity tests indicated that BCP was toxic at high concentration, whereas its toxicity was completely reversed by concomitant DHA administration."
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"Further, we found that DHA inhibited the activation of the NF-KB signaling pathway."
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"Singer et al., suggested that EPA and DHA could inhibit NFKB activity at several levels during NF-kappaB pathway [XREF_BIBR]."
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"The epoxides of both EPA and DHA, formed by the action of CYP enzymes, also inhibit NFkB inflammatory signaling via PPAR activation."
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"DHA, with targeting lipopolysaccharides (LPS) surface receptor, suppresses NFkB activity and the production of inflammatory cytokines in microglia."
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"Remarkably, treatment with DHA alone or DHA in combination with NAC decreased both NF-κB (p65) and NF-κB (p50) activities in LPS-stimulated cells by 1.8 and 1.6 fold for DHA alone, and 2.3 and 1.9 fol[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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