IndraLab

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USP2 increases the amount of SKP2. 3 / 3
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"Given that USP2 knockdown reduced the levels of both SKP2 and SKP2 substrates, p21 and p27 (Fig. 6B), this growth inhibitory effect appears to be mediated by other substrates of USP2 in a manner largely independent of SKP2."
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"Consistently, knockdown of USP2, but not USP21, reduced endogenous levels of SKP2 in three lung cancer cell lines (Fig. 1C), suggesting USP2, but not USP21, is likely an SKP2 deubiquitylase."
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"We found that while both USP2-WT and USP2–C276A rescued the levels of SKP2 substrates, only USP2-WT restored SKP2 protein levels (Fig. 5H)."
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