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USP18 inhibits viral RNA genome replication. 2 / 2

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"However, the interaction with MAVS could not explain the observed effects of USP18 in this study, where USP18 deficiency enhanced the release of mtDNA to the cytosol and suppressed viral replication."

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"Taken together, USP18 may reduce cGAS degradation by deubiquitinating it thereby maintaining cGAS-STING pathway activation.Finally, we determined that cGAS-STING pathway is involved in USP18-mediated [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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IndraLab

Statements

USP18 inhibits viral RNA genome replication. 2 / 2

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