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IFI27 inhibits USP18. 3 / 3
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"Collectively, these findings indicated that elevated IFI27 reversed the repression of USP18 knockdown on cell malignant development and DDP resistance in DDP‐resistant ESCC cells.3.5 HOXA5 Directly Bound the Promoter of USP18."
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"Furthermore, a series of rescue experiments demonstrated that IFI27 upregulation partially reversed the repression of USP18 deficiency on DDP resistance, cell proliferation, and metastasis in DDP‐resistant ESCC cells."
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"Taken together, these results indicated that HOXA5 could repress IFI27 expression by modulating USP18 in DDP‐resistant ESCC cells.4 Discussion."
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