IndraLab

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USP1 inhibits cell population proliferation. 14 / 14
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"Thus, we made a conclusion that targeting USP1 could reduce the proliferation of HCC cells.4 DISCUSSION."
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"CCK8 assays and colony formation assays showed that circUSP1 promoted GC cell viability and proliferation, which was suppressed by the knockdown of USP1 and Vimentin (Supplementary Fig. S5i, Fig. 5m)."
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"USP1 downregulation decreased expressions of fibrosis related genes, suppressed proliferation, and promoted apoptosis in TGF-beta1-induced LX-2 cells, which were reversed by SNAIL overexpression."
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"Taken together, our study found that downregulated USP1 decreased OV cell proliferation."
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"More importantly, inhibition of USP1 with its inhibitor ML323, a specific USP1-UAF1 inhibitor, significantly inhibited the glycolysis and proliferation of T-ALL cells."
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"Further, ML323 targets USP1, thereby inhibiting the proliferation of OV cells by blocking the progression of the OV cell cycle, thus achieving inhibition of tumor proliferation."
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"Both inhibition of USP1 with shRNA knockdown and pimozide treatment inhibited cell proliferation and induced autophagy and cell cycle arrest in DLBCL cells.As a deubiquitylation enzyme, USP1 binds to the target proteins and maintains their stability by removing the ubiquitylation chain."
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"Targeting USP1 could decrease the proliferation of HCC cells via cell cycle arrest."
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"Depletion of Usp1 decreases epidermal proliferation in Fancd2 (+/-) mice."
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"Recently, several studies indicated that USP1 had been found to be upregulated in many kinds of tumors, and they also found that deregulated USP1 could suppress cell proliferation, migration, invasion, chemo-resistance (40,41)."
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"The result showed liver cancer cell proliferation was significantly inhibited by USP1-KD (Fig. S4, C and D)."
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"Collectively, our results suggest that silencing USP1 inhibits cell proliferation and invasion in U2OS cells."
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"The proliferation of GSCs is suppressed by depletion of β-catenin, USP1 or EZH2, which is rescued by overexpression of EZH2 K421R/Y641F mutant."
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"We found that overexpression of MAX or MYC significantly rescued USP1 knockdown-induced inhibition of cell proliferation in RL-4RH cells (Fig. 5a, b)."
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