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USP8 activates autophagy. 4 / 5
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"These data indicate that USP8 guards autophagic flux in ESCs.EPG5 mediates autophagy by direct binding to LC3 using its LIR motif , which is conserved in eukaryotes (Fig. 6e)."
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"We show here that UBPY silencing also activates autophagy in absence of CCCP treatment, which strongly suggests that UBPY is not connected exclusively to mitophagy."
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"Inactivation of human UBPY in HeLa cells activates autophagy."
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"Lastly, we have shown that shRNA mediated inactivation of UBPY in HeLa cells also affects autophagy which appears to be deregulated with an increased number of autophagosomes and increased autophagy flux."
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