IndraLab

Statements


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"Westphalen and colleagues 40 found that deletion of TREK-1 significantly reduced the inhibitory effect of halothane on glutamate release from cerebrocortical nerve terminals, which implies that reduced excitatory transmission is a possible mechanism of neuroprotective effect of anaesthetic preconditioning."

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"TREK-1 deletion also reduced halothane inhibition of basal glutamate release, but did not affect basal GABA release."

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"Deletion of TREK-1 significantly reduced the potency of halothane inhibition of 4-aminopyridine-evoked release of both glutamate and GABA without affecting control evoked release or the selective inhibition of glutamate vs GABA release."