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USP46 increases the amount of NRAS. 1 / 1
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"As shown in Fig. 5a, the depletion of USP46 in genetically engineered human immortalized melanocytes (hTERT/CDK4 /p53 ) expressing NRAS Q61R significantly decreased the protein level of NRAS and suppressed the activation of downstream pathways assessed by p-AKT and p-ERK."