IndraLab

Statements

Sirolimus inhibits IFNB1. 7 / 7
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"IFN-β and ISRE promoter activity was significantly upregulated by 3-MA, but was downregulated by rapamycin, suggesting the negative regulatory role of autophagy in antiviral innate immunity ( Fig. 1 A[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35914352
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"Rapamycin additionally diminished the IFNbeta response to CpG-A and CpG-B in DNA-PKcs- or DNA-PKcs and Ku70-deficient BMDCs (XREF_FIG)."
25812014
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"Including rapamycin increased the survival of established tumor bearing mice, as rapamycin treatment reduced the local IFNb production."
23726825
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"The results showed that rapamycin inhibited the activation of IRF-3, NF-κB, and IFN-β, while ly294002 enhanced the activation (Figure 5)."
35805093
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"As shown in XREF_FIG, both anti--IFNAR2 antibody and rapamycin inhibited IFNbeta induction of OAS2 RNA; inhibition by anti--IFNAR2 was rapid (within 24 h), while inhibition by rapamycin was only evident at 72 hr."
28107341
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"Rapamycin also significantly inhibited pDC secretion of IFN-beta, TNF and IL-6 (XREF_FIG and XREF_SUPPLEMENTARY online)."
18758466
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"Interestingly, IFN-β induction in this study appeared to be suppressed by rapamycin but not completely blocked, suggesting mTOR-independent effects (or at least mTORC1-independent effects as mTORC2 ma[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29746850