IndraLab

Statements

USP7 activates angiogenesis. 6 / 6
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"It has been shown that USP7 mediates pathophysiological angiogenesis by regulating the Sp1/Sp3-Notch1 signaling pathway in response to angiotensin-converting enzyme inhibitor (ACEI) [11]."
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"The silencing of USP7 could impair CC cell proliferation, migration, invasion, and angiogenesis, as well as suppress macrophage M2 polarization."
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"Collectively , these data indicated that FOXO6 promoted the proliferation and angiogenesis of EC by mediating USP7 expression via the JMJD3 / CLU pathway ."
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"USP7 silencing suppresses CC cell proliferation, migration, invasion, angiogenesis and macrophage M2 polarization."
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"USP7 inhibition induced more apoptosis and suppressed angiogenesis in USP22-Ko cancer cells."
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"we found that USP7 inhibition didn’t modulate angiogenesis in the parental A549 xenografts but did further decrease angiogenesis in USP22-Ko A549 xenografts (Fig. 7C), while no significant change of USP7 IHC was observed in these xenograft tissues, indicating the effect is mainly through its deubiquitinating activity."
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