IndraLab

Statements

PPP1R13B binds OTUB1. 6 / 6
| 3 3
reach
"The interaction between ASPP1 and OTUB1 facilitates the ubiquitination and subsequent degradation of p53, thereby contributing to the activation of cardiac fibroblasts and the development of myocardial fibrosis."
39341821
sparser
"Mechanistically, ASPP1 is directly bound to deubiquitinase OTUB1, thereby promoting the ubiquitination and degradation of p53, attenuating myofibroblast activity and cardiac fibrosis, and improving heart function after MI."
39341821
sparser
"Since OTUB1 functions as a deubiquitinase, we examined whether the interaction between ASPP1 and OTUB1 alters the ubiquitination and degradation of p53 in cardiac fibroblasts."
39341821
reach
"In this study, we demonstrated that ASPP1 acted as a positive regulator of cardiac fibrosis by binding to OTUB1 to enhance p53 ubiquitination and degradation."
39341821
reach
"These data indicate that OTUB1 mediates the regulation of ASPP1 on p53 protein level.Since OTUB1 functions as a deubiquitinase, we examined whether the interaction between ASPP1 and OTUB1 alters the ubiquitination and degradation of p53 in cardiac fibroblasts."
39341821
sparser
"The interaction between ASPP1 and OTUB1 facilitates the ubiquitination and subsequent degradation of p53, thereby contributing to the activation of cardiac fibroblasts and the development of myocardial fibrosis."
39341821