IndraLab

Statements

Tetrodotoxin inhibits SCN9A. 6 / 8
2 | 4
ctd
No evidence text available
17522141
ctd
No evidence text available
23382806
reach
"The current subsets identified by TTX have been demonstrated to depend on specific voltage-gated sodium channels (VGSC): TTX-sensitive (TTX-S) sodium channels, such as Nav1.1, Nav.1.3, Nav1.6 and Nav1.7 which are blocked by TTX at nanomolar concentrations, and TTX-resistant (TTX-R) sodium channels, such as Nav1.8 and Nav1.9 which are blocked by TTX only at micromolar concentrations (Dib-Hajj et al., 2009)."
26548414
reach
"The recombinant human PN1 currents exhibited rapid activation and inactivation kinetics and were blocked by TTX with a half-maximal inhibitory concentration (IC50) of 32.6 nM."
14527872
reach
"Hainantoxin-III is a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels; wherein it suppresses Nav1.7 current amplitude without altering any activation, inactivation, and repriming kinetics (Liu et al., 2013)."
34604795
reach
"Hainantoxin-III is a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels; wherein it suppresses Nav1.7 current amplitude without altering any activation, inactivation, and repriming kinetics ."
34604795