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3',5'-cyclic AMP inhibits IFNB1. 2 / 2
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"As shown in Fig. 4 B, inhibition of PKA activity by H-89 increased the effect of luteolin on ISRE reporter expression, whereas increasing intracellular cAMP with 8-Br-cAMP further inhibited the effect[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, overexpression of the dominant-negative c-Fos mutant A-Fos ( Olive et al., 1997 ) cancelled the suppressive effect of cAMP on LPS-induced TNF-α and IFN-β mRNA upregulation ( Figure S2 )."
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