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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Gamma1 activates KCNMA1. 2 / 2

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"Although both gamma1 and gamma2 modulate the BK channel very effectively, the gamma2 and gamma1-TM chimera, which resulted from gamma1 's TM segment being in the presence of gamma2 's LRRD and C-tail, was ineffective (i.e., the resultant V 1/2 is within 15 mV of that produced by BKalpha alone) in modulating BK channel voltage gating (V 1/2 = 155 +/- 4 mV) (XREF_FIG), suggesting that incompatibility exists between the gamma1 TM segment and either the gamma2 LRRD or the gamma2 C-tail."

26009545

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"Therefore, the physical association or interaction between the BKgamma TM segments and BKalpha may be a main mechanism by which the gamma1 and gamma2 subunits modulate BK channel voltage dependent gating."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...