IndraLab

Statements

USP32 activates BAG3. 3 / 3
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"Mechanistic investigations revealed that BAG3 is a substrate for USP32, and that USP32 directly interacts with BAG3 to promote NSCLC carcinogenesis through blocking BAG3 degradation."
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"We then looked at whether USP32 inhibited BAG3 degradation in a way that was dependent on proteasomes."
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"The findings demonstrated that USP32 overexpression in H1299 cells extended the BAG3 protein’s half-life (Fig. 4A), while USP32 knockdown accelerated the degradation of BAG3 in A549 cells (Fig. 4B)."
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