IndraLab

Statements

TNF-R32W binds TNFRSF1A. 2 / 2
| 2
reach
"Indeed, mutated R32W and S86T TNFalpha binds to TNFR1, whereas mutated D143N and A145R exclusively binds to TNFR2, suggesting that different subdomains of TNFalpha modulate its specificity towards TNF[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22152226
reach
"Previous studies have demonstrated that human TNF mutants R32W-S86T selectively bound only to TNF-R1, whereas D143N-A145R bound only to TNF-R2 ( Loetscher et al., 1993; Van Ostade et al., 1994 )."
19232662