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BAP1 inhibits Melanocytes. 1 / 1
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"For instance , while loss of Bap1 activates intrinsic apoptosis in several mouse cell types ( hepatocytes , keratinocytes , fibroblasts , and embryonic stem cells ) in an RNF2-dependent fashion , the Bap1 loss enhances proliferation of melanocytes in association with upregulation of lineage-specific oncogenes MITF and BCL2 , independently of RNF2 ( 48 ) ."