IndraLab

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USP15 leads to the deubiquitination of CBX5. 4 / 4
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"More importantly, USP15 reduced the ubiquitination of CBX5 protein and promoted its expression in PASMCs.CBX5 is a chromobox protein of the HP1 family and a methyl reader that interprets H3K9me2/3 marks mediated by H3K9 methyltransferases (i.e., SUV39H1 and SUV39H2) [33]."
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"Co-IP experiments further showed that USP15 overexpression reduced the ubiquitination of CBX5, whereas USP15 knockdown promoted the ubiquitination of CBX5 (Figure 5D)."
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"Taken together, these results indicate that USP15 can reduce the ubiquitination of CBX5 protein, thereby enhancing its stability."
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"This study investigated PH-related molecular interactions in PASMCs and found: 1) RUNX1 promotes hypoxia-induced PASMC dysfunction and PH; 2) RUNX1 transcriptionally activates the expression of USP15; 3) USP15 reduces CBX5 ubiquitination and promotes CBX5 expression; and 4) RUNX1 regulates PASMC function through the USP15/CBX5 axis.RUNX1 is a master developmental regulator essential for hematopoietic cell differentiation and normal hematopoiesis [21]."
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