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UCHL1 deubiquitinates HIF1A. 3 / 3
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"UCHL1 deubiquitinates HIF-1alpha protein and upregulates HIF-1 activity in murine breast cancer derived EMT6 cells."
28761052
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"Moreover, when the ubiquitination status of the HIF-1alpha protein was directly evaluated by performing immunoprecipitation assays, the knockdown of endogenous UCHL1 significantly increased HIF-1alpha ubiquitination (XREF_FIG and XREF_SUPPLEMENTARY)."
25615526
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"We revealed that <span class="match term0">UCHL1</span> directly interacts with <span class="match term1">HIF-1ALPHA</span>, mediates the deubiquitination of <span class="match term1">HIF-1ALPHA</span>, and upregulates HIF-1 activity through the stabilization of HIF1alpha"
28778421