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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

UCHL1 deubiquitinates HIF1A. 3 / 3

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ubibrowser

"We revealed that UCHL1 directly interacts with HIF-1α, mediates the deubiquitination of HIF-1α, and upregulates HIF-1 activity through the stabilization of HIF1α"

28778421

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reach

"UCHL1 deubiquitinates HIF-1alpha protein and upregulates HIF-1 activity in murine breast cancer derived EMT6 cells."

28761052

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reach

"Moreover, when the ubiquitination status of the HIF-1alpha protein was directly evaluated by performing immunoprecipitation assays, the knockdown of endogenous UCHL1 significantly increased HIF-1alpha ubiquitination (XREF_FIG and XREF_SUPPLEMENTARY)."

25615526

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...