IndraLab

Statements

Ato decreases the amount of KCNH2. 3 / 3
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"ATO or Ang II inhibited HERG protein expression in cardiomyocytes."
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"Immunoblot analysis indicated that GA treatment partially abolished PML SUMOylation that was induced by ATO or Ang II, consequently reversing the decreased HERG protein expression caused by ATO and Ang II."
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"Mechanistically, an increase in PML SUMOylation by ATO or Ang II dramatically enhanced the formation of PML and Pin1 complexes in PML-NBs, leading to the upregulation of TGF-beta1 protein, eventually inhibiting HERG expression through activation of protein kinase A."
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