IndraLab

Statements

OTUB1 activates FGFR2. 6 / 6
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"Interestingly, OTUB1 inhibits FGFR2 degradation through lysosome, consistent with FGFR2 being a membrane protein."
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"OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2."
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"Research indicates that E3 ubiquitin ligases are involved in regulating osteoblast differentiation and bone formation, such as OTUB1 promoting bone formation by stabilizing FGFR2, and Parkin inhibiting RANKL-induced osteoclastogenesis."
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"Finally, new research has discovered that OTUB1 enhances the activity of the FGFR2 signaling pathway by stabilizing FGFR2 and preventing its degradation."
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"In this study, we unveil the positive role of OTUB1 in osteoblast-mediated bone formation by maintaining FGFR2 stability and the osteogenesis effects of OTUB1 provide an optical therapeutic strategy to alleviate osteoporosis."
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"To unravel which mechanism is involved in OTUB1-mediated FGFR2 regulation, we mutated E2-binding residue aspartic acid (D) 88, catalytic core residues cysteine (C) 91 and histidine (H) 265 in OTUB1."
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