IndraLab

Statements

Polycomb inhibits KCNA5. 4 / 4
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"We recently showed that polycomb dependent repression of KCNA5 contributes to Ewing sarcoma cell survival under conditions of hypoxia."
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"Thus, we hypothesized that tolerance of hypoxic stress in cancer cells might be mediated by polycomb dependent repression of the KCNA5 locus."
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"Our results implicate polycomb dependent epigenetic repression of KCNA5 as a key mechanism of channel inhibition and reveal the critical role of this inhibition in promoting cancer cell survival under conditions of microenvironmental stress, in particular hypoxic stress."
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"KCNA5 is repressed by polycomb in cancer cells."
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