IndraLab

Statements

BRCC3 inhibits ferroptosis. 5 / 5
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"Recent research has suggested that BRCC36 inhibits ferroptosis by stabilizing 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in a DUB-dependent manner [37]."
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"Furthermore, BRCC36 promoted cell proliferation, migration, and invasion, while inhibiting ferroptosis and inducing pyroptosis in liver cancer cells."
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"Therefore, these findings indicate that depletion of BRCC36 promotes ferroptosis and inhibits pyroptosis primarily by regulating HMGCR expression.2.6 BRCC36 Functions as an Oncogene in Hepatic Carcinoma."
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"We also found that BRCC36 inhibits ferroptosis and regulates pyroptosis, which is dependent on HMGCR expression."
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"These results suggest that BRCC36 directly deubiquitinates HMGCR.2.5 BRCC36 Inhibits Ferroptosis and Promotes Pyroptosis."
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