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USP22 deubiquitinates FASN. 5 / 5
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"Together, these results support that USP22 interacts with FASN and inhibits FASN ubiquitination in CRC cells."
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"In p53 wild-type colorectal cancer (CRC) cells, hydrogen peroxide (H 2 O 2 )-induced p53 expression represses the transcription of deubiquitinase USP22, which otherwise deubiquitinates and stabilizes Fatty Acid Synthase (FASN), and thus inhibits fatty acid synthesis."
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"Whereas, depletion of USP22 in RKO E6 cells promoted FASN ubiquitination (Fig. 2E)."
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"We have found H O -induced p53 expression inhibits the transcription of USP22, which otherwise deubiquitinates and stabilizes FASN."
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"Overexpression of USP22 decreased FASN ubiquitination in the presence of MG132 (Fig. 2D and Fig. S2D)."
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