IndraLab

Statements

UCHL3 activates cell population proliferation. 13 / 13
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"UCHL3 promotes proliferation of colorectal cancer cells by regulating SOX12 via AKT and mTOR signaling pathway."
33194042
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"Regulating biological functions, UCHL3 promoted GSC proliferation, tumorigenesis, self-renewal, and radioresistance in a POLD4-dependent manner.The degradation of POLD4 by ubiquitin ligases in response to DNA damage and during cell cycle progression plays a less prominent role in normal cells [43], while with increasing insights into the complex mechanisms of DNA damage repair, POLD4 is projected to play an increasingly important role."
38829550
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"UCH-L3 promotes non small cell lung cancer proliferation via accelerating cell cycle and inhibiting cell apoptosis."
32180254
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"Furthermore, autophagy was significantly enhanced along with the decrease in NEDD8 ubiquitination.In conclusion, the results of the present study demonstrated that UCHL3 knockdown decreased melanoma cell proliferation by increasing cell autophagy through regulating NEDD8 expression and autophagosome numbers in vitro."
34539860
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"UCHL3 promoted pancreatic cancer cell proliferation and migration by deubiquitinating FOXM1 (20)."
36969045
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"UCHL3 depletion repressed cell proliferation and migration both in vitro and in vivo."
38266402
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"UCH-L3 knockdown significantly inhibited the proliferation of NSCLC cells, whereas UCH-L3 overexpression had the opposite effect."
32180254
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"Moreover, UCH-L3 promoted NSCLC cells proliferation via accelerating cell cycle and inhibiting cell apoptosis."
32180254
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"Colony formation assays indicated that POLD4 overexpression restored the proliferation ability reduced by UCHL3 depletion in the case of IR (Fig. 6C)."
38829550
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"As expected, overexpressing UCHL3 favored the proliferative and migratory activity of bladder cancer cells, and UCHL3 depletion caused reduced bladder cancer cell proliferation and migration."
37740194
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"Therefore, UCHL3 increased EJ cell proliferation, viability, migration and invasion, and these effects depended on its deubiquitinating activity."
37740194
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"Thus, UCHL3 deficiency impairs T24 cell proliferation and migratory function in vitro."
37740194
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"Taken together, the results of the present study suggest that UCHL3 knockdown decreases melanoma cell proliferation by increasing cell autophagy through regulating NEDD8 expression and autophagosome numbers."
34539860