IndraLab

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ALKBH5 increases the amount of USP1. 3 / 3
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"Moreover, ALKBH5 can upregulate the expression of USP1, which mediates the glucocorticoid-resistance in T-ALL patients and cells via interacting with Aurora B [141]."
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"ALKBH5, by reducing m A, enhances ubiquitin‐specific protease 1 (USP1) expression that regulates chemoresistance by upregulating Aurora B. 80 Thus, m A modification regulates apoptosis in cancer therapy resistance (Table 5 ).4.4 Induction of DNA Damage Repair."
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"Mechanistically, ALKBH5 enhanced USP1 expression by reducing m6A level and mRNA stability in USP1 mRNA transcript."
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