IndraLab

Statements

OTUB1 activates immune response. 5 / 5
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"This effect of OTUB1 is dependent on its catalytic activity and promotes immune response in dendritic cells (Mulas et al., 2021)."
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"In this context, OTUB1 might be a potential target for new therapies of OSCC.As a key and star deubiquitinating enzyme, OTUB1 mediates ferroptosis, immunity, apoptosis, and autophagy in tumor and non-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In contrast, OTUB1 might be summoned to activate the immune response to infectious pathogens."
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"Mice lacking Otub1 in astrocytes show severe central nervous system autoimmunity, and dendritic cell-specific deletion of Otub1 impairs the immune response of dendritic cells during infection and inflammation."
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"Consistently, the inducible Otub1 ablation greatly enhances antitumor immunity, characterized by increased numbers of tumor infiltrating T cells, NK cells, and cDC1, and the intratumoral cDC1 increase in Otub1 deficient mice is dependent on NK cells."
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