IndraLab

Statements

OTUB2 activates cell migration. 4 / 4
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"Knockdown of OTUB2 significantly inhibited cell migration and invasive ability, and ZEB1 overexpression could reverse this phenomenon as confirmed in in vitro experiments."
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"Additionally, while our findings suggest that OTUB2 promotes TNBC cell migration, this conclusion is based solely on in vitro assays, and we lack in vivo metastasis models to further validate its role in tumor dissemination."
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"Conversely, the knockdown of OTUB2 resulted in slower wound healing, reinforcing the Transwell results and confirming that OTUB2 depletion inhibits TNBC cell migration (Fig. 4E,F)."
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"Meanwhile, in vitro experiments confirmed that the reduction in cell migration and invasion ability caused by low OTUB2 expression could be attenuated by CTNNB1 overexpression."
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