IndraLab

Statements

Cholesterol decreases the amount of KCNMA1. 3 / 3
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"To determine whether the channel degradation process is involved in the reduction of KCa1.1 protein expression by cholesterol enrichment, the classical proteasome inhibitor lactacystin XREF_BIBR and the lysosomal function inhibitor bafilomycin A1 XREF_BIBR were applied in BK-HEK 293 cells."
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"However, in BK-HEK 293 cells expressing both KCa1.1 and auxiliary beta1-subunits, cholesterol enrichment decreased the current density and KCa1.1 protein expression."
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"The present study has demonstrated that the cholesterol enrichment reduces the current density, single channel open probability and KCa1.1 protein expression level in BK-HEK 293 cells."
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