IndraLab

Statements

UCHL1-I93M inhibits Ubiquitin. 2 / 2
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"Notably, the I93M UCHL1 mutant has markedly reduced ubiquitin hydrolase activity in vitro [XREF_BIBR], suggesting that impaired polyubiquitin hydrolysis could also contribute to dopaminergic neuronal death."
18047737
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"Notably, the I93M UCHL1 mutant display markedly reduced ubiquitin hydrolase activity in vitro; suggesting that impaired polyubiquitin hydrolysis leading to a shortage of free ubiquitin might also promote the accumulation of toxic proteins and contribute to neuronal death."
24532982