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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

UCHL1-I93M inhibits Ubiquitin. 2 / 2

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"Notably, the I93M UCHL1 mutant display markedly reduced ubiquitin hydrolase activity in vitro; suggesting that impaired polyubiquitin hydrolysis leading to a shortage of free ubiquitin might also promote the accumulation of toxic proteins and contribute to neuronal death."

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"Notably, the I93M UCHL1 mutant has markedly reduced ubiquitin hydrolase activity in vitro [XREF_BIBR], suggesting that impaired polyubiquitin hydrolysis could also contribute to dopaminergic neuronal death."

18047737

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...