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RIPK1 activates CYLD. 1 / 1

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"The intimate involvement of CYLD in necrotic death was elucidated in a landmark paper by Moquin and colleagues that detailed CYLD mediated regulation of TNFalpha induced necrosis by deubiquitination of RIPK1 in MEF and L929 cells, while, conversely, CYLD downregulation by Toll Like Receptors protects mouse macrophages from necrosis [XREF_BIBR, XREF_BIBR]."

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RIPK1 activates CYLD. 1 / 1

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