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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

RIPK1 activates CYLD. 1 / 1

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"The intimate involvement of CYLD in necrotic death was elucidated in a landmark paper by Moquin and colleagues that detailed CYLD mediated regulation of TNFalpha induced necrosis by deubiquitination of RIPK1 in MEF and L929 cells, while, conversely, CYLD downregulation by Toll Like Receptors protects mouse macrophages from necrosis [XREF_BIBR, XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...