IndraLab

Statements

OTUB2 is sumoylated on K233. 4 / 4
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sparser
"In mouse breast cancer cells, OTUB2 is SUMOylated at the Lys233 site after translation, and modified OTUB2 relies on this modification to interact with SUMO-interacting motif (SIM) of YAP/TAZ to perform its deubiquitination function, ultimately affecting cancer metastasis ( xref )."
35309903
sparser
"OTUB2, a deubiquitinating cysteine protease, has been shown to deubiquitinate and activate YAP/TAZ in RAS-transformed MCF10A cells, which is dependent on poly-SUMOylation of OTUB2 on lysine 233 ( xref ) [ xref ]."
36264492
sparser
"Nowadays, for the modification regulation of OTUB2, only SUMOylation of the Lys233 site of OTUB2 is confirmed to interact with Yes-associated protein/transcriptional co-activator with PDZ-binding motif (YAP/TAZ), thereby enhancing the activity of OTUB2 and mediating the transfer of ubiquitin ( xref )."
35309903
sparser
"Interestingly, OTUB2 is sumoylated on Lys 233, which promotes its association with Yap/Taz via a conserved but previously uncharacterized SUMO-interacting motif (SIM) in Yap/Taz ( xref )."
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