IndraLab

Statements

LIFR binds OSM and OSMR. 5 / 5
| 5
sparser
"This loop is located near the "FXXK" motif in active site III, which is essential for OSM's binding to both LIFR and OSMR."
22829597
sparser
"It exerted its biological function by binding to two different OSM receptor complexes, OSMR-β and LIFR [ xref ]."
34037532
sparser
"Shortening of the loop enhanced OSM's interaction with OSMR and LIFR as shown by kinetic and equilibrium binding analysis, suggesting the loop may hinder receptor interactions."
22829597
sparser
"Here, we show that the MES-like state is not only correlated with macrophage abundance but is directly induced by them, specifically through macrophage-secreted OSM that interacts with OSMR or LIFR (in complex with GP130) on glioblastoma cells, thereby activating STAT3."
34087162
sparser
"Upon brain infiltration, macrophages release several cytokines and ligands such as oncostatin M, which binds to the oncostatin M receptor and leukemia inhibitory factor receptor that signals through the signal transducer and activator of transcript 3 pathway to induce the MES-like transcriptional program in glioma cells [ xref ]."
| PMC