IndraLab

Statements

USP18 increases the amount of PRKAA2. 4 / 4
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"POU4F1 promoted transcription of AMPK-alpha2 (PRKAA2) and USP18 modulated PRKAA2 protein level via affecting POU4F1."
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"Western blot (Fig. 7D) and IHC (Fig. 7E) demonstrated that knockdown of USP18 or POU4F1 significantly downregulated the protein level of PRKAA2 in tumor tissues from mice, which was then offset following upregulation of POU4F1 or PRKAA2."
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"Our level analysis demonstrated that USP18 promoted PRKAA2 expression by enhancing de-ubiquitination of POU4F1.However, there are some limitations in the current study."
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"All in all, POU4F1 could promote PRKAA2 transcription and USP18 upregulated PRKAA2 expression via the deubiquitination of POU4F1."
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