IndraLab

Statements

CTNNB1 phosphorylated on S45 leads to the phosphorylation of CTNNB1 on S33. 2 / 2
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"CK-1-dependent phosphorylation of β-catenin at Ser 45 provides a recognition site for GSK-3, and allows it to phosphorylate β-catenin at positions Thr 41 , Ser 37 , and Ser 33 ( Liu et al., 2002 )."
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"It is established that Ser45 phosphorylation by casein kinase I (CKI) initiates phosphorylation at Thr41, Ser37, and Ser33 by glycogen synthase kinase 3 (GSK3) and that phosphorylated Ser37 and Ser33 are recognized by the F-box protein beta-TrCP, a component of a ubiquitin ligase complex that mediates beta-catenin degradation."
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