IndraLab

Statements

72 phosphorylates NPM1. 6 / 6
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"The vCyclin and CDK6 complex also phosphorylates nucleophosmin (NPM), facilitating NPM-LANA interaction and recruitment of HDAC1 to regulate KSHV latency [XREF_BIBR]."
21625290
sparser
"The vCyclin-CDK6 complex also phosphorylates nucleophosmin (NPM), facilitating NPM-LANA interaction and recruitment of HDAC1 to regulate KSHV latency [ xref ]."
21625290
reach
"The notion that v-cyclin phosphorylates NPM in patient derived PEL cells was supported by recent identification of NPM Thr199 CycE-Cdk2 phosphorylation site as a target of v-cyclin-CDK6 in vitro XREF_BIBR."
20333249
reach
"The v-Cyclin and CDK6 kinase also mediates phosphorylation of nucleophosmin (NPM) an indirect target of ATM, on threonine 199 in de novo and naturally KSHV infected cells."
27258263
reach
"The exact role of this viral protein in regulating KSHV life cycle is not fully understood but studies indicate that v-Cyclin mediates phosphorylation of nucleophosmin (NPM), through its association with CDK6 and facilitates NPM-LANA interaction and recruitment of HDAC1 to promote KSHV latency [XREF_BIBR]."
25514370
reach
"Additionally, v-Cyclin and CDK6 phosphorylation of NPM facilitates the interaction of LANA with the histone deacetylase HDAC1 to promote KSHV latency [XREF_BIBR]."
27258263