IndraLab

Statements

USP22 activates Carcinoma, Hepatocellular. 13 / 14
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"USP22 promotes the proliferation of hepatocellular carcinoma cells by stabilising CDK11B and enhances resistance to Sorafenib by inhibiting ferroptosis through the USP22/H2BK120ub/TFRC axis.So far, more than 40 USPs have been directly or indirectly associated with relevant cancer processes."
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"In contrast, other studies have shown that USP22 promotes fatty acid synthesis in hepatocellular carcinoma cells and, thus, hepatocellular carcinoma progression ."
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"After we had confirmed that USP22 promotes the growth of hepatocellular carcinoma, we further focused on exploring whether USP22 regulates Sorafenib resistance in hepatocellular carcinoma."
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"To further validate that USP22 increases hepatocellular carcinoma cell proliferation by stabilising CDK11B protein, we overexpressed His‐CDK11B in USP22 knockout cells (Figure 4F) and evaluated cell proliferation."
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"Our data further indicates that USP22 promotes the proliferation of hepatocellular carcinoma cells via deubiquitinating and stabilizing cyclin-dependent kinase 11B (CDK11B)."
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"Why USP22 has a preference for H2BK120ub as its substrate under Sorafenib treatment is worth further research.In summary, our study demonstrated that USP22 promotes the growth of hepatocellular carcinoma and resistance to Sorafenib‐induced ferroptosis by removing ubiquitin moieties from non‐histone protein CDK11B and histone H2B."
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"Altogether, these results provided evidence that USP22 promotes the proliferation of hepatocellular carcinoma cells by stabilising CKD11B and increases Sorafenib resistance through reducing H2BK120ub level and TFRC transcription in vivo.3 DISCUSSION."
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"For example, USP22 can stabilize the E2F6 stability and activate Akt pathway in hepatocellular carcinoma (HCC), leading to aggressive progression of HCC (25)."
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"19 However, there has been a lack of thorough investigation into the role of USP22 in hepatocellular carcinoma development and Sorafenib resistance.In this study, we demonstrate that USP22 promotes the proliferation of hepatocellular carcinoma cells by stabilising cyclin‐dependent kinase 11B (CDK11B)."
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"USP22 promotes MDR in hepatocellular carcinoma cells partly by activating the SIRT1/Akt/MRP1 pathway [ 17 ]."
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"We have demonstrated that USP22 depletion inhibits hepatocellular carcinoma cell proliferation and promotes the sensitivity of hepatocellular carcinoma cells to Sorafenib‐induced ferroptosis by in vitro assays."
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"2.1 USP22 promotes the proliferation of hepatocellular carcinoma cells."
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"The USPs family is the largest and most important DUB family, and many of these elements are involved in the occurrence and development of multiple cancers, such as USP1, USP4, USP7, USP22, and USP28, which promote or inhibit the development and progression of colorectal, breast, and hepatocellular carcinomas via deubiquitining the hub genes of cancer-related signaling pathways [10, 11]."
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