IndraLab

Statements

USP47 inhibits MYC. 6 / 6
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"Therefore, USP47 acts in a YTHDF1-dependent manner to inhibit m A-dependent c-Myc translation and maintain Treg metabolism and homeostasis."
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"Here, we identified that the deubiquitinase USP47 inhibited c-Myc translation mediated by the RNA N 6 -methyladenosine (m 6 A) reader YTHDF1 to maintain Treg metabolic and functional homeostasis."
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"USP47 deficiency in Tregs triggered the accumulation of the c-Myc protein and in turn exacerbated hyperglycolysis."
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"RNA sequencing and biochemical and metabolic analysis demonstrated that USP47 deficiency promoted c-Myc protein accumulation and hyperglycolysis, which contributed to defective Treg homeostasis."
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"Therefore, USP47 inhibits excessive c-Myc activity and hyperglycolysis in Tregs."
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"USP47 inhibits m 6 A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis."
37788092