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EMMAA Bob with Bioagents

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP25 activates FOXP3. 4 / 4

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"Here USP21 prevents FOXP3 degradation most likely through removing K48 linked polyubiquitin moieties."

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"USP21 prevents the loss of FOXP3 protein in Treg cells."

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"Therefore, USP21 prevents the proteasomal degradation of FOXP3 in Treg cells."

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"Interestingly, Foxp3 directly activates expression of USP21, and siRNA knockdown of USP21 downregulates both GATA3 and Foxp3 protein."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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