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P-menthan-3-ol inhibits ITCH. 19 / 19
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"Finally, we show that B5-I neurons are innervated by menthol-, capsaicin-, and mustard oil responsive sensory neurons and are required for the inhibition of itch by menthol."
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"Menthol and other counterstimuli relieve itch, resulting in an antipruritic state that persists for minutes to hours."
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"Finally, we show that B5-I neurons are innervated by menthol-, capsaicin-, and mustard oil-responsive sensory neurons and are required for the inhibition of itch by menthol."
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"Together, these data suggest that B5-I neurons mediate the inhibition of itch by menthol and likely other chemical counterstimuli."
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"To directly test this possibility, we developed a mouse model of inhibition of itch by menthol."
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"Moreover, we show that menthol inhibits itch in wild-type mice but does not do so in mice lacking B5-I neurons."
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"Finally, we demonstrate that B5-I neurons are innervated by capsaicin-, mustard oil-, and menthol-responsive primary afferents and are required for inhibition of itch by menthol."
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"These findings suggest that B5-I neurons are required for the inhibition of itch by menthol (XREF_FIG B)."
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"Together, these data suggest that B5-I neurons mediate the inhibition of itch by menthol and likely other chemical counterstimuli."
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"Finally, we show that, whereas menthol inhibits itch in wild-type mice, it does not do so in mice that lack B5-I neurons."
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"Finally, we demonstrate that B5-I neurons are innervated by capsaicin-, mustard oil-, and menthol responsive primary afferents and are required for inhibition of itch by menthol."
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"These findings suggest that B5-I neurons are required for the inhibition of itch by menthol ( xref B)."
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"Direct evidence that dynorphin released from spinal interneurons is involved in suppressing itch was provided by showing that chloroquine-evoked itch could be inhibited by menthol in wild-type mice, but not inBhlhb5 −/− mice, in which the dynorphin cells are largely absent. xref "
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"To directly test this possibility, we developed a mouse model of inhibition of itch by menthol."
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"XREF_BIBR, XREF_BIBR - XREF_BIBR Of note, menthol at concentrations of 1 to 3% have been reported to relieve pruritus, while higher dose preparations such as 10% solutions can induce irritation."
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"In contrast, Bhlhb5 -/- mice showed no significant inhibition of itch by menthol (XREF_FIG A)."
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"In contrast,Bhlhb5 −/− mice showed no significant inhibition of itch by menthol ( xref A)."
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"Finally, we show that, whereas menthol inhibits itch in wild-type mice, it does not do so in mice that lack B5-I neurons."
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"Moreover, we show that menthol inhibits itch in wild-type mice but does not do so in mice lacking B5-I neurons."
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