IndraLab

Statements

Drug inhibits JAK1. 6 / 6
| 5 1
eidos
"This drug inhibits JAK1 , JAK2 , JAK3 and Tyk2 enzyme activity with IC 50 values of 3.9 , 5.0 , 0.71 and 4.8 nM , respectively ."
| PMC
eidos
"These drugs preferentially inhibit JAK-1 and JAK-3 ; JAK-1 and JAK-2 ; and JAK-1 , respectively ."
33444321
eidos
"Others have also suggested using drugs that inhibit JAK1 / 2 to help patients with COVID-19 [ 59 , 60 , 61 , 62 , 63 , 80 , 81 , 82 ] ."
| DOI
reach
"Baricitinib, is not only expected to interrupt the passage and intracellular assembly of SARS-CoV-2 into the target cells mediated by ACE2 receptor, but also promises to be a specific drug that blocks cytokine storms by suppressing JAK1/JAK2 [6]."
| PMC
eidos
"Others have also suggested using drugs that inhibit JAK1 / 2 to help patients with COVID-19 [ 59 ] [ 60 ] [ 61 ] [ 62 ] [ 63 ] [ 80 ] [ 81 ] [ 82 ] ."
34791019
eidos
"Since these two drugs also inhibit JAK1 and block the IL-6 signaling pathway , any inhibitory effect on GM-CSF alone remains unclear ."
| PMC